"Fame is complicated and definitely overrated. There are perks to it that are unfathomable. But the other aspect is there's little to no privacy at all - being anywhere at any time and knowing that somebody you cannot see is probably taking a picture of you, which has happened hundreds of times. I look around and cannot see anyone and a couple of weeks later I see a photo of me looking around."

"My tendency is towards the opposite of health and taking care of myself. My natural tendency is destructive. In order not to act on that, I have to be careful. The minute I don't feel like that, if I let down my guard, I'm in trouble."

"I often showed up ungroomed. It didn't occur to me. Then I'd end up at a premiere and I'd think, what are you doing? I remember being at a restaurant with a famous British actress. I knew there were paparazzi outside. My intention was to make a beeline for the car. But then, as we were walking outside, she applied lipstick. I thought, what is she doing? But her public image is very glamorous. It's a different mindset."

"I don't show my face [in L.A.] very much, and so that makes it a bit more complicated for me in terms of work. They [producers] need to see you in the press, and in their face, in meetings, auditions, whatever. And as far as they're concerned, I haven't provided enough of an example of the kind of things that I can do, as an actor, for them to justify hiring me without me sitting down in front of them or having me dance around."

"I don't usually like seeing things I'm in. I get really depressed afterward."

"I walked in thinking, it's going to be like riding a bicycle. It wasn't. It was like riding a unicycle. I'd been trying so hard to stretch myself in other roles, and to catch myself when I did anything that remotely resembles Scully, that when I was put back in the ring with her, my brain started misfiring." [quoted in The New York Times, July 13, 2008, on how unexpectedly hard it was for her to get back in character as Scully for the movie The X Files: I Want to Believe (2008) five years after the end of the television series.]